Biomarker Discovery program utilizes patient oriented genetic, statistical modeling and risk factor association approaches. The aim of conducting genetic screening of various neurological disorders is to understand the disease process by investigating the role of environment and genes in determining the disease susceptibility in patients. We are also initiating whole genome studies for various diseases with the goal of strengthening the molecular diagnostic component of our research program so that the new biomarkers can be discovered for evaluating disease burden. We usually base our analysis on body fluids such as blood, lymphocytes and CSF of patients, neurological controls and healthy volunteers and carry out extensive statistical analysis for purposes of clinical correlation and risk factor analysis. All investigations are cleared from Institute Ethical Committee. In future, we plan to sample Brain autopsies and establish Brain Bank apart from undertaking neuropsychological analysis. Most of these investigations are conducted in collaboration with clinical faculty.