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Toshiki Mizuno

Toshiki Mizuno
Division of Neurology and Gerontology
Kyoto Prefectural University of Medicine, Japan

E-mail: neurokpu@koto.kpu-m.ac.jp

Our research interests include diverse classes of neurological disorders, such as dementias, cerebrovascular diseases, neurodegenerative diseases, and neuromuscular diseases. We have been undertaking diagnostic studies on wide variety of dementias including Alzheimer disease, hereditary vascular dementias, and idiopathic normal pressure hydrocephalus (iNPH) by different modalities of neuroradiological investigations (SPECT, PET, and diffusion-weighted MR imaging), protein analysis on amyloid, tau, and TDP-43 proteins, and genetic analysis.

On cerebrovascular diseases, we have been investigating part of the pathogenesis using fiber-tracking method, and also the therapeutic possibilities on selective cerebral hypothermia. Other research topics encompasses Parkinson disease, spinocerebellar degeneration, amyotrophic lateral sclerosis, Charcot-Marie-Tooth disease, mitochondrial diseases, Alexander disease, HTLV-I associated myelopathy and diverse types of myopathies.

Our department also covers the research on cognitive impairment due to dementia and stroke and the studies on reward and dopaminergic system. In addition, our clinical service division offers genetic counseling, genetic testing, and pathological diagnosis on muscle biopsies.

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